Sec61-IN-5

Sec61-IN-5 (Compound 16c) is a Sec61 inhibitor. Sec61 shows cytotoxicity in A549 cells (IC50: 0.27 nM) . Sec61-IN-5 inhibits Sec61-dependent secretory function (IC50: 0.08 nM) [1].

C70H113N11O14

1332.71

CN(C)[C@H](C(O[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(N(C)[C@H](C(N(C)[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@H](C(N[C@H](C1=O)CC2=CC=C(C=C2)C3=CC=CC=C3)=O)CC(C)C)=O)C)=O)=O)COC)=O)[C@H](NC([C@@H](C)N1C)=O)C)=O)=O)COC)C)=O)C(C)C)=O)C(C)C

Others

10 mM in DMSO

Room temperature