SET2 is a selective TRPV2 antagonist (IC50=0.46 μM) . SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator) -induced cytoplasmic calcium increases[1].
CAS Number
[2313525-20-9]
Molecular Formula
C17H21F3N4O2S
Molecular Weight
402.43
Smiles
O=C(CCSC1=NC(C(F)(F)F)=CC(N(CCC)C)=N1)NCC2=CC=CO2
Target
TRP Channel
Isoform
TRPV2
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)