SH-053-S-CH3-2'F [CAS 872874-00-5]

SH-053-S-CH3-2'F is a selective positive allosteric modulator that produces mild to partial agonistic activity at α (1) GABA (A) receptors. SH-053-S-CH3-2'F showed anxiety-relieving effects at a dose of 30 mg/kg. SH-053-S-CH3-2'F completely avoids the memory impairment commonly caused by benzodiazepine site agonists. SH-053-S-CH3-2'F shows strong selectivity at GABA (A) receptors, which could potentially be used to develop more selective anti-anxiety drugs[1].

[872874-00-5]

C23H18FN3O2

387.41

O=C(C1=C2N(C=N1)C3=CC=C(C#C)C=C3C(C4=CC=CC=C4F)=N[C@H]2C)OCC

GABA Receptor

Room temperature