SH-E4A-66

SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide) . SH-E4A-66 is capable of coupling with EML4-ALK (EC50=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC50=2.3 μM) [1].

C24H18ClN3O3

431.87

O=C(N1C(C=CC=C2)=C2C3=C1C=CC=C3)C4=CC(NC(C=C)=O)=CC(NC(CCl)=O)=C4

Anaplastic lymphoma kinase (ALK)

Room temperature