SHP2-IN-42

SHP2-IN-42 is a src homology 2 domain-containing phosphatase 2 (SHP2) inhibitor with an IC50 of 15 nM. SHP2-IN-42 inhibits cell proliferation and induces apoptosis and G1 phase cell cycle arrest. SHP2-IN-42 can be used for the research of cancer, such as acute myeloid leukemia (AML) [1].

C27H30N6O4

502.56

C[C@@H]1OCC2([C@@H]1N)CCN(CC2)C3=NN4C=CC(C5=CC=C(C=C5)N6C=CC=C6C(O)=O)=C4C(N3C)=O

Apoptosis; Phosphatase; SHP2

Room temperature