SHP2-IN-8 [CAS 1801692-60-3]

SHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the ΔTm of 7.01 °C. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells[1].

[1801692-60-3]

C17H21Cl2N5S

398.35

NC1=NC(N2CCC(C)(CN)CC2)=CN=C1SC3=CC=CC(Cl)=C3Cl

Akt; Apoptosis; Phosphatase; SHP2

10 mM in DMSO

Room temperature