SHR5428 [CAS 3054791-71-5]

SHR5428 is a potent, orally active, selective and noncovalent inhibitor of CDK7 with highly potent CDK7 enzymatic activity (IC50=2.3 nM) . SHR5428 inhibits triple negative breast cancer cellular activity on MDA-MB-468 cell (IC50=6.6 nM) [1].

[3054791-71-5]

C22H23F3N5O2P

477.42

CP(C1=C(C=CC2=C1NC=C2C3=C(C=NC(N[C@@H]4C[C@H](CCC4)O)=N3)C(F)(F)F)C#N)(C)=O

CDK

CDK1; CDK12; CDK2; CDK4; CDK6; CDK7; CDK9

10 mM in DMSO

Room temperature