Name: SIAIS178 [CAS 2376047-73-1]
Brand: QuantiMol
SKU: QM-0142567-01
Price: 301.5 GBP
Availability: InStock

Product Details

Description
SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity[1].
CAS Number
[2376047-73-1]
Molecular Formula
C50H62ClN11O6S2
Molecular Weight
1012.68
Smiles
O=C(N1CCN(C2=NC(C)=NC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=C2)CC1)CCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](O)C5)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O
Target
Bcr-Abl; PROTACs
Isoform
Von Hippel-Lindau (VHL)
Purity
99.36
Solubility
DMSO : 300 mg/mL (ultrasonic)
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping Conditions
Room Temperature

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Variant	Variant total	Quantity	Price	Variant total
1 mgQM-0142567-01	1 mgQM-0142567-01 £301.50/ea	£0.00	Quantity	£301.50/ea	£0.00

5 mgQM-0142567-02	5 mgQM-0142567-02 £652.64/ea	£0.00	Quantity	£652.64/ea	£0.00

10 mM - 1 mLQM-0142567-03	10 mM - 1 mLQM-0142567-03 £712.17/ea	£0.00	Quantity	£712.17/ea	£0.00

10 mgQM-0142567-04	10 mgQM-0142567-04 £865.26/ea	£0.00	Quantity	£865.26/ea	£0.00

50 mgQM-0142567-05	50 mgQM-0142567-05 £2,497.01/ea	£0.00	Quantity	£2,497.01/ea	£0.00

100 mgQM-0142567-06	100 mgQM-0142567-06 £3,501.82/ea	£0.00	Quantity	£3,501.82/ea	£0.00

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SIAIS178 [CAS 2376047-73-1]

SIAIS178 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.