Sibiriline [CAS 1346526-26-8]

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SKU:QM-0139979

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Description
Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis.[1].
CAS Number
[1346526-26-8]
Molecular Formula
C13H10N2O
Molecular Weight
210.23
Smiles
OC1=CC=C(C=C1)C2=CC3=CC=CN=C3N2
Target
Apoptosis; Necroptosis; RIP kinase
Shipping Conditions
Room temperature
Hazard Statement
H302-H315-H319-H335
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Sibiriline is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.