SIK-IN-1 [CAS 3033846-29-3]

SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SIK1, SIK2 and SIK3 with IC50s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS -induced IL-10 release with EC50 of 4 nM in human macrophages[1].

[3033846-29-3]

C23H24N6OS

432.54

N#CC1=C(NC)C=CC2=NC=C(C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3)N21

AMPK

98.91

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature