SIK2-IN-3 [CAS 2810809-10-8]

SIK2-IN-3 is an orally active SIK1/2 selective inhibitor (IC50: 0.128/0.084 μM) . SIK2-IN-3 inhibits CRTC3 phosphorylation and myeloid cell pro-inflammatory cytokine production. SIK2-IN-3 ameliorates systemic and tissue inflammatory responses in a mouse anti-CD40 colitis model[1].

[2810809-10-8]

C23H24N6O2

416.48

CN(C1)CC[C@H]1COC2=CN=C(C#N)C=C2C3=CC4=CC(NC(C5CC5)=O)=NN4C=C3

Salt-inducible Kinase (SIK)

SIK1; SIK2

Room temperature