Silatecan [CAS 220913-32-6]

Silatecan (AR-67; DB 67) is a Camptothecin analogue with improved stability and lipophilicity. Silatecan is an inhibitor for topoisomerase I, that inhibits the DNA replication and transcription, and exhibits antitumor and radiosensitizing activities[1]

[220913-32-6]

C26H30N2O5Si

478.61

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C([Si](C)(C(C)(C)C)C)C5=CC(O)=CC=C5N=C4C3=C2)=O

Topoisomerase

Topo I

Room temperature

H301

P264-P270-P330-P405-P501