Silymarin is an extract of the milk thistle (Silybum marianum) . Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC) . Silymarin has the potential for COVID-19 research[1][2][4].