SIN 14

SIN 14, a derivative of Sinomenine , is an orally active HO-1 activator (KD = 17.2 μM). SIN 14 binds to the catalytic core domain of HO-1 and induces HO-1 activation in catalysis. SIN 14 significantly increases HO-1 stability. SIN 14 has anti-inflammatory effects and inhibits M1 macrophage polarization while promoting M2 polarization in LPS (Lipopolysaccharides) (HY-D1056) -induced RAW264.7 cells. SIN 14 inhibits inflammatory mediator production (eg: NO, IL-6, IL-1β and CCL2, inhibits production of ROS and down-regulates the expression of COX-2 and iNOS. SIN 14 can inhibit RA-related inflammatory edema in collagen-induced arthritis (ClA) mice[1].

C20H22ClNO4

375.85

COC1=CC=C2C[C@H](N3C)C4[C@@]5(CC3)C(C(O)OC1=C52)=C(Cl)C(OC)=C4

COX; Heme Oxygenase (HO) ; Interleukin Related; NO Synthase; Reactive Oxygen Species (ROS)

COX-2; HO-1; IL-1; IL-6; iNOS

Room temperature