Sirt1/2-IN-1 [CAS 2402779-21-7]

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].

[2402779-21-7]

C22H13ClN2OS2

420.93

O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21

Microtubule/Tubulin; Sirtuin

SIRT1; SIRT2; SIRT3

10 mM in DMSO

Room temperature