SJ1461 [CAS 2924546-70-1]

SJ1461 is a potent and orally active BET inhibitor. SJ1461 inhibits BRD2 (BD1), and BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM, respectively[1].

[2924546-70-1]

C21H18ClN7OS2

484

CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NC5=NN=CS5)=O

Epigenetic Reader Domain

BRD2; BRD4

10 mM in DMSO

Room temperature