SJ46420

SJ46420, a SJ46421 pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-13030) ; Black: linker (HY-20797) ; Blue: E3 ligase ligand (HY-159973) ).

C43H43ClN8O5S2

851.44

O=C(OC)CNC(CC1=CSC(C2=CC=C3C=CC=C(OCCN4CCN(C(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)CC4)C3=C2)=N1)=O

Epigenetic Reader Domain; PROTACs

BRD3; von Hippel-Lindau (VHL)

Room temperature