SJF-0661 [CAS 2413035-43-3]

SJF-0661 is a variant of the von Hippel-Lindau (VHL) protein ligand with no targeted degradation ability and can be used as a control reagent for the VHL ubiquitin ligase ligand. SJF-0661 is a variant obtained by inverting the stereocenter of the key hydroxyproline group in the VHL ligand[1].

[2413035-43-3]

C51H57F2N9O7S2

1010.18

O=C(C1=C(C(NS(CCC)(=O)=O)=CC=C1F)F)C2=CNC3=NC=C(C4=CC=C(N5CCN(CC5)CC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@@H](C6)O)C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)C=C4)C=C23

Ligands for E3 Ligase

Von Hippel-Lindau (VHL)

99.2

10 mM in DMSO

-20°C, 3 years (Powder)

Blue Ice