SJF-1528 (hemihydrate)

SJF-1528 (PROTAC 1) hemihydrate is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 hemihydrate also degrades HER2. SJF-1528 hemihydrate promotes ubiquitination and degradation of EGFR and can be used in breast cancer research (Pink: ligand for target protein ; Black: linker Tos-PEG2-CH2-Boc (HY-130532) ; Blue: ligand for E3 ligase (S, R, S) -AHPC (HY-125845) ).

C55H57ClFN7O8S.1/2H2O

1039.62

O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7.[1/2].O

EGFR; PROTACs

98.9

DMSO : 104 mg/mL (ultrasonic;warming)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice