SJL2-1

SJL2-1 is a PRMT5 inhibitor, with an IC50 of 1.56 μM. SJL2-1 suppresses proliferation, migration, and invasion in prostate cancer cells. SJL2-1 promotes apoptosis and blocks the cell cycle at the G0/G1 phase. SJL2-1 can target the binding of PRMT5 in cells and inhibit the methylation and expression of the androgen receptor. SJL2-1 can be used for the study of early androgen-sensitive prostate cancer and advanced castration-resistant prostate cancer (CRPC) [1].

C22H26N2O

334.45

CC1=CN(CC(CN2C(C)C(C=CC=C3)=C3CC2)O)C4=CC=CC=C41

11β-HSD; Androgen Receptor; Histone Methyltransferase

Room temperature