SK2188 [CAS 3038446-94-2]

SK2188 is a highly efficient and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM). SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 ; Blue: Thalidomide (HY-14658) ; Black: Linker: Amino-PEG4-alcohol (HY-W008005) ).

[3038446-94-2]

C43H46ClFN6O10S

893.38

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=C3C1=O

Apoptosis; Aurora Kinase; Caspase; PROTACs

Aurora A; Caspase 3; Caspase 7; Cereblon

99.87

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature