SKF 38393 [CAS 67287-49-4]

SKF 38393 is a selective dopamine D1 receptor agonist. SKF 38393 activates the cAMP signaling pathway and promotes dopamine release in the developing rat striatum. SKF 38393 inhibits MCF-7 breast cancer cell proliferation (IC50=0.1 μM) . SKF 38393 is promising for research of neurodevelopmental disorders, dopamine-related diseases (e.g., Parkinson’s, dopamine deficiency), and cancers[1][2].

[67287-49-4]

C16H17NO2

255.31

OC1=C(O)C=C(C(CNCC2)C3=CC=CC=C3)C2=C1

Dopamine Receptor

D1 Receptor

10 mM in DMSO

Room temperature