SL44

SL44 is an agonist for human caseinolytic protease P (HsClpP), with an EC50 of 1.30 μM. SL44 inhibits the proliferation of LM3 with an IC50 of 3.1 μM. SL44 induces apoptosis in HCC cells, through the degradation of respiratory chain complex subunits. SL44 exhibits antitumor efficacy in mouse models without obvious toxicity (LD50=400 mg/kg) . SL44 exhibits good pharmacokinetic characters in rat models[1].

C22H20ClFN4O

410.87

ClC1=C(F)C=CC(CC2=NOC(C3CCN(CC4=CC=CC(C#N)=C4)CC3)=N2)=C1

ClpP

99.57

DMSO : 70 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice