SMA4

SMA4 is a selective PKG1α activator with basal EC50 value of 29 μM. SMA4 facilitates phosphorylation of the known PKG1 substrate, vasodilator-stimulated phosphoprotein (VASP), and inhibits human pulmonary arterial smooth muscle cells (hPASMC) proliferation. SMA4 can be used for cardiovascular disease research[1].

C28H27Cl2N3O4

540.44

[H][C@]1(C2=CC=CC=C2)[C@](O[C@@H](CO)C3=CC(Cl)=CC(Cl)=C3)([H])CCCN1CC4=NC5=C(N4)C=CC(C(O)=O)=C5

PKG

98.52

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature