SMARCA2-IN-10 [CAS 82131-85-9]

SMARCA2-IN-10 (Compound 4) is a highly selective SMARCA2 ATPase domain inhibitor (IC50=17.676 μM) . SMARCA2-IN-10 induces cell death in SMARCA4-deficient tumors. SMARCA2-IN-10 is promising for research of SMARCA4-mutant non-small cell lung cancer, small cell ovarian carcinoma, and melanoma[1].

[82131-85-9]

C28H20N2O7

496.47

O=C(C1=CC=CC=C1C(O)=O)NC2=CC=C(OC3=CC=C(NC(C4=CC=CC=C4C(O)=O)=O)C=C3)C=C2

Epigenetic Reader Domain

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501