SMART1

SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models. (Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L) ) [1].

C40H35N9O7

753.76

CNC(C1=NC=CC(OC2=CC=C(C=C2)N3C=C(N=N3)C4=CC(NC(C5CCCN(C5)C6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CC=C4)=C1)=O

Akt; PDK-1; PROTACs

99.87

DMSO : ≥ 100 mg/mL

-20°C, 3 years (Powder)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335