SNIPER (ER) -87 [CAS 2222354-91-6]

SNIPER (ER) -87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM) . SNIPER (ER) -87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER (ER) -87-induced ERα degradation[1][2].

[2222354-91-6]

C59H73N5O10S

1044.3

C[C@H](NC)C(N[C@@H](C1CCCCC1)C(N2[C@H](C3=NC(C(C4=CC=CC(OCCOCCOCCOCC(N(C)CCOC5=CC=C(/C(C6=CC=C(O)C=C6)=C(C7=CC=CC=C7)\CC)C=C5)=O)=C4)=O)=CS3)CCC2)=O)=O

Estrogen Receptor/ERR; SNIPERs

10 mM in DMSO

Room temperature