SNT-8370

SNT-8370 is an orally active inhibitor of VAP-1 (IC50: 10 nM) and myeloperoxidase (MPO) (IC50: 17 nM), with >100-1000 fold more potency for VAP-1 and MPO versus other mammalian (per) oxidases. SNT-8370 inhibits MPO-mediated LDL lipid peroxidation. SNT-8370 inhibits leukocyte infiltration in lung injury models of acute inflammation. SNT-8370 is an anti-inflammatory agent, and can be used for research of inflammatory disorders[1].

C16H16FN5O2S

361.39

O=C1C2=C(N=CN2)N(CC3=CC=CC(OC/C(CN)=C/F)=C3)C(N1)=S

Glutathione Peroxidase; VAP-1

Room temperature