Sob-AM2 [CAS 2128258-47-7]

Sob-AM2 is a potent substrate (Km=1.3 μM) targeting fatty acid amide hydrolase (FAAH) expressed in the brain and has blood-brain barrier permeability. Sob-AM2 delivers high concentrations of Sobetirome to the central nervous system with minimal peripheral systemic dose, thereby stimulating central thyroid hormone receptor β (TRβ). In addition, Sob-AM2 can prevent myelin and axon degeneration in experimental autoimmune encephalomyelitis (EAE) mice[1].

[2128258-47-7]

C21H27NO3

341.44

O=C(COC1=CC(C)=C(CC2=CC=C(C(C(C)C)=C2)O)C(C)=C1)NC

FAAH; Thyroid Hormone Receptor

98.5

DMSO : 20 mg/mL (ultrasonic;warming)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature