Sodium dichloroacetate [CAS 2156-56-1]
Sodium dichloroacetate [CAS 2156-56-1]
SKU:QM-0119533-01
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Product Details
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Description
Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na+-K+-2Cl− cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS) . Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers[1][2].
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CAS Number
[2156-56-1]
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Molecular Formula
C2HCl2NaO2
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Molecular Weight
150.92
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Smiles
O=C(O[Na])C(Cl)Cl
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Target
Apoptosis; NKCC; PDHK; PDK-1; Reactive Oxygen Species (ROS)
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Purity
99.78
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Solubility
H2O : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319, H335, H351
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Precautions
H315, H319, H335, H351
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Sodium dichloroacetate [CAS 2156-56-1]
Sodium dichloroacetate is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.