Sorafenib-13C, d3 [CAS 1210608-86-8]
Sorafenib-13C, d3 [CAS 1210608-86-8]
SKU:QM-0081752-01
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Product Details
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Description
Sorafenib-13C, d3 is the 13C- and deuterium labeled Sorafenib. Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].
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CAS Number
[1210608-86-8]
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Molecular Formula
C20 13CH13D3ClF3N4O3
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Molecular Weight
468.84
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Smiles
O=C(NC(C=C1)=CC=C1OC2=CC(C(N[13C]([2H])([2H])[2H])=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3
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Target
Apoptosis; Autophagy; Ferroptosis; FLT3; Raf; VEGFR
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Purity
98.35
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Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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Sorafenib-13C, d3 [CAS 1210608-86-8]
Sorafenib-13C, d3 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.