Sorafenib-d3 (tosylate) [CAS 1333386-17-6]
Sorafenib-d3 (tosylate) [CAS 1333386-17-6]
SKU:QM-0002528
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Product Details
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Description
Sorafenib-d3 (Donafenib-d3) tosylate is the deuterium labeled Sorafenib. Sorafenib is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib-d3tosylate is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib-d3tosylate induces autophagy and apoptosis. Sorafenib-d3tosylate has anti-tumor activity. Sorafenib is a ferroptosis activator[1].
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CAS Number
[1333386-17-6]
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Molecular Formula
C28H21D3ClF3N4O6S
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Molecular Weight
640.05
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Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.[2H]C([2H])([2H])NC(C2=CC(OC3=CC=C(C=C3)NC(NC4=CC(C(F)(F)F)=C(C=C4)Cl)=O)=CC=N2)=O
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Target
Apoptosis; Autophagy; Ferroptosis; FLT3; Isotope-Labeled Compounds; Raf; VEGFR
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Shipping Conditions
Room temperature
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Sorafenib-d3 (tosylate) [CAS 1333386-17-6]
Sorafenib-d3 (tosylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.