SOS1-IN-20

SOS1-IN-20 (Compound 12f) is an orally active SOS1 inhibitor with an IC50 of 5.11 nM against KRASG12C::SOS1. By disrupting the interaction between KRAS and SOS1, SOS1-IN-20 inhibits KRAS activation and downstream signal transduction. SOS1-IN-20 has an IC50 of 253 nM for p-ERK in PC-9 cells and 16.71 μM for hERG channel . SOS1-IN-20 can inhibit the proliferation of tumor cells and has antitumor activity[1].

C21H23F3N4O

404.43

C[C@H](C1=CC=CC(C(F)F)=C1F)NC(C2=CC(C3CC3)=CN=C2NC4CNC4)=O

Potassium Channel; Ras; SOS1

Room temperature