SOS1-IN-5 [CAS 2716956-47-5]

SOS1-IN-5 is a potent inhibitor of SOS1. SOS1-IN-5 is a pyrimidobicyclic derivative. SOS1-IN-5 blocks the activation of KRAS by interfering with RAS-SOS1 interaction, and achieves the purpose of broad-spectrum inhibition of KRAS activity. SOS1-IN-5 has the potential for the research of cancer diseases (extracted from patent WO2021203768A1, compound 4) [1].

[2716956-47-5]

C26H31F3N4O5

536.54

C[C@H](C1=CC(C(F)(F)F)=CC(N)=C1)NC2=NC(C)=NC3=C2C=C(OCCOCCOCCOCCO4)C4=C3

Ras; SOS1

10 mM in DMSO

Room temperature