Sotorasib-d7

Sotorasib-d7 (AMG-510-d7) is a deuterium-labeled Sotorasib. Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC)[2][3].

C30H23D7F2N6O3

567.64

O=C(C=C)N1C([2H])([2H])[C@H](C([2H])([2H])[2H])N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)C([2H])([2H])C1

Isotope-Labeled Compounds; Ras

K-Ras

98.9

DMSO : ≥ 100 mg/mL

-20°C (Powder, stored under nitrogen)

Blue Ice