Spadin (TFA)

Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research[1][2].

C92H143F3N26O24

2126.36

N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CO)NC([C@H](C(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]3N(C(CNC([C@H](CO)NC([C@H](CC4=CNC5=CC=CC=C45)NC([C@H](CCCNC(N)=N)NC([C@H]6N(C([C@H](CC(C)C)NC([C@H]7N(C([C@H](C)NC([C@H](CC8=CC=C(C=C8)O)N)=O)=O)CCC7)=O)=O)CCC6)=O)=O)=O)=O)=O)CCC3)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(F)C(O)=O

5-HT Receptor; Potassium Channel

99.73

H2O : 25 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Blue Ice