SPC-180002 [CAS 2170274-53-8]

SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway[1].

[2170274-53-8]

C18H23NO4

317.38

O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC

Keap1-Nrf2; Reactive Oxygen Species (ROS) ; Sirtuin

SIRT1; SIRT3

10 mM in DMSO

Room temperature