SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1][2].
CAS Number
[68181-17-9]
Molecular Formula
C12H12N2O4S2
Molecular Weight
312.37
Smiles
O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2
Target
ADC Linker
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Purity
99.14
Solubility
DMSO : 250 mg/mL (ultrasonic)
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)