Specnuezhenide ((8E) -Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E) -Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E) -Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) [1].