SRT6

SRT6, an anticancer agent is a CD44 inhibitor. SRT6 inhibits key CD44-associated kinases, including SRC, ERBB2 and MAPKAPK2. SRT6 has strong tumor selectivity over non-tumoral lung cells and significant antiproliferative activity against cancer cells (EC50of 1.37 μM for NCI-H23 cells) [1].

C25H26N2O8S

514.55

O=S(C1=CC=C([N+]([O-])=O)C=C1)(OC2=CC=CC3=C2CCN(CC4=CC(OC)=C(OC)C(OC)=C4)C3)=O

CD44; EGFR; MAPKAPK2 (MK2) ; Src

Room temperature