SS47 [CAS 2636072-62-1]

SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the antitumor efficacy[1].

[2636072-62-1]

C49H56N6O12S

953.07

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCCOCCOCCC(N4CCC(C5=NC=C(C6=CC(OCC7=CC=CC(C#CC(C)(O)C)=C7)=C(N)N=C6)S5)CC4)=O)=O

MAP4K; PROTACs

MAP4K1/HPK1

10 mM in DMSO

Room temperature