Ssm spooky toxin

Ssm Spooky Toxin is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC50s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system[1] [2][3].

C270H413N69O79S4

6017.84

O=C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]6[C@H](O)C)=O)NC7=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(NCC(O)=O)=O)=O)=O)=O)=O)NC6=O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H]([C@H](O)C)C(NCC(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCCCN)C(N%11[C@@H](CCC%11)C(NCC(N[C@@H](CC%12=CC=CC=C%12)C(N[C@@H](CC%13=CC=CC=C%13)C(N[C@H]7CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N

Potassium Channel

Voltage-gated potassium channel

10 mM in DMSO

Room temperature