ST171

ST171 is a bitopic 5-HT1AR agonist with an Ki of 0.41 nM. ST171 selectively activates Gi/o signaling pathway and inhibits 5-HT1AR-mediated cAMP accumulation without Gs activation and marginal β-arrestin recruitment. T171 reduces hypersensitivity in chronic neuropathic and inflammatory pain mice model. ST171 can be used for pain research[1].

C20H24N2O5

372.41

COC1=CC=CC=C1OCCNCCCOC2=CC=C3OCC(NC3=C2)=O

5-HT Receptor

5-HT1 Receptor

99.3

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature