Stavudine [CAS 3056-17-5]

Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) . Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA) . Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

[3056-17-5]

C10H12N2O4

224.22

OC[C@H]1O[C@@H](N2C=C(C)C(NC2=O)=O)C=C1

Apoptosis; Autophagy; HIV; NOD-like Receptor (NLR) ; Nucleoside Antimetabolite/Analog; Reverse Transcriptase

HIV-1; HIV-2; NLRP3

99.87

DMSO : 125 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H341, H373

H341, H373