STF-1084 [CAS 2298390-71-1]

STF-1084 is a specific, cell-impermeable, competitive inhibitor of ENPP1 (Ki = 33 nM) . STF-1084 increases extracellular cGAMP concentrations by preventing its degradation by ENPP1, thereby enhancing immune infiltration. STF-1084 acts synergistically with ionizing radiation (IR) and cGAMP to delay tumor progression. STF-1084 can be used to study cancers with low immunogenicity[1].

[2298390-71-1]

C17H24N3O5P

381.36

OP(O)(CCC1CCN(C2=C3C=C(OC)C(OC)=CC3=NC=N2)CC1)=O

Phosphodiesterase (PDE)

99.7

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H312, H315, H318, H332, H335

H302, H312, H315, H318, H332, H335