STK899704 [CAS 1578247-29-6]

STK899704 is a tubulin polymerization inhibitor. STK899704 exhibits broad-spectrum inhibitory activity against various cancer cell lines with IC50 values ​​ranging from 0.2 to 1.0 μM. STK899704 disrupts the mitotic spindle structure, inducing G2/M phase cell cycle arrest. STK899704 inhibits the migration ability of HT29 cells by downregulating the FAK-MEK-ERK signaling pathway, thereby suppressing the expression and activity of MMP-2 and MMP-9. STK899704 activates caspase-3/7/8/9, leading to PARP cleavage and inducing apoptosis. STK899704 induces cellular senescence through the p53 pathway. STK899704 can be used in research on skin cancer, lung cancer, colon cancer, and other cancers[1][2][3].

[1578247-29-6]

C27H23N3O4

453.49

O=C(OCC)CN1C(C)=C(/C=N/NC(C2=CC3=C4C=CC=CC4=CC=C3O2)=O)C5=C1C=CC=C5

Apoptosis; Caspase; ERK; FAK; MDM-2/p53; MEK; Microtubule/Tubulin; MMP; PARP

Caspase 3; Caspase 7; Caspase 8; Caspase 9; ERK; MEK; MMP-2; MMP-9

Room temperature