Streptonigrin [CAS 3930-19-6]

Streptonigrin (Bruneomycin) is an orally active antibiotic and pan-PAD inhibitor, inhibiting PAD1, PAD2, PAD3 and PAD4 with IC50 of 48.3 μM, 26.1 μM, 0.43 μM and 2.5 μM, respectively. Streptonigrin inhibits SENP1 (IC50 of 0.518 μM) and reduces HIF1α. Streptonigrin increases p53 and Apoptosis. Streptonigrin shows antiviral activity against Rauscher murine leukemia virus. Streptonigrin has immunosuppressive effects. Streptonigrin has antitumor activity against osteosarcoma[1][2][3][4][5][6][7][8][9][10].

[3930-19-6]

C25H22N4O8

506.46

O=C(C1=NC(C2=NC3=C(C(C(OC)=C(N)C3=O)=O)C=C2)=C(N)C(C4=CC=C(OC)C(OC)=C4O)=C1C)O

Antibiotic; Apoptosis; E1/E2/E3 Enzyme; HIF/HIF Prolyl-Hydroxylase; MDM-2/p53; Protein Arginine Deiminase

HIF-1α

99.2

10 mM in DMSO

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H300

H300