Streptozotocin [CAS 18883-66-4]

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA (DNA-methylating) . Streptozotocin can induce the apoptosis of β cells[1][2][3].

[18883-66-4]

C8H15N3O7

265.22

O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](NC(N(C)N=O)=O)[C@H]1O

Antibiotic; Apoptosis; Autophagy; Bacterial; DNA Alkylator/Crosslinker; DNA/RNA Synthesis

99.2

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

-20°C (Powder, sealed storage, away from moisture and light)

Blue Ice

H228, H341, H351

H228, H341, H351