Sunitinib (glucuronate) [CAS 1818285-48-1]

Sunitinib (SU 11248) glucuronate is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib glucuronate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

[1818285-48-1]

C28H37FN4O9

592.61

O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O.O=C(/C(C1=C2)=C\C3=C(C(C(NCCN(CC)CC)=O)=C(N3)C)C)NC1=CC=C2F

Apoptosis; Autophagy; IRE1; Mitophagy; PDGFR; VEGFR

PDGFRβ; VEGFR2/KDR/Flk-1

95

-20°C, 3 years (Powder)

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