SX 011 [CAS 309913-42-6]

SX 011 is a p38 inhibitor with IC50s of 9 nM and 90 nM against p38α and p38β, respectively. SX 011 also inhibits JNK-2 with an IC50 of 100 nM. SX-011 is orally bioavailable[1].

[309913-42-6]

C26H27ClFN3O3

483.96

O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3CCC(CC4=CC=C(F)C=C4)CC3)=O)C(Cl)=C2)=O

JNK; p38 MAPK

JNK1; JNK2; p38α; p38β; p38γ; p38δ

99.33

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature